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Brca2tm1Mhun
Targeted Allele Detail
Nomenclature
Symbol: Brca2tm1Mhun
Name: breast cancer 2, early onset; targeted mutation 1, MC Hung
MGI ID: MGI:3055613
Gene: Brca2  Location: Chr5:150522630-150570329 bp, + strand  Genetic Position: Chr5, 89.52 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:89083
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 2kb 3' region of exon 11 was replaced with a neomycin resistance gene. Targeting was confirmed by Southern blot analysis. (J:89083)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Brca2 Mutation:  76 strains or lines available
References
Original:  J:89083 Yan DH, et al., A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene. 2004 Mar 11;23(10):1896-901
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory