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Targeted Allele Detail
Symbol: Prkntm1Rpa
Name: parkin RBR E3 ubiquitin protein ligase; targeted mutation 1, Richard D Palmiter
MGI ID: MGI:3055212
Gene: Prkn  Location: Chr17:10840384-12063361 bp, + strand  Genetic Position: Chr17, 7.8 cM, cytoband A3.2-A3.3
Germline Transmission:  Earliest citation of germline transmission: J:95204
Parent Cell Line:  AK18.1 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsApproximately 4 kb of the genomic sequence containing exon 2 were replaced with a construct containing the neor gene, driven by the polymerase (RNA) II (DNA directed) polypeptide A gene promoter, and the negative selection markers HSV-TK and PGK-DTA. (J:95204)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prkn Mutation:  30 strains or lines available
Original:  J:95204 Perez FA, et al., Parkin-deficient mice are not a robust model of parkinsonism. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2174-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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