Prkag3tm1Sson
Targeted Allele Detail
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Symbol: |
Prkag3tm1Sson |
Name: |
protein kinase, AMP-activated, gamma 3 non-catalytic subunit; targeted mutation 1, Leif Andersson |
MGI ID: |
MGI:3055131 |
Synonyms: |
AMPKgamma3 KO, gamma3 AMPK KO, Prkag3- |
Gene: |
Prkag3 Location: Chr1:74778081-74788380 bp, - strand Genetic Position: Chr1, 38.54 cM
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Alliance: |
Prkag3tm1Sson page
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Germline Transmission: |
Earliest citation of germline transmission:
J:92821
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Insertion
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Mutation details: The insertion of a neomycin resistance gene resulted in the transcription of exons 1-4 joined to exons 11-13, with a frame shift after residue 211 and a premature stop codon at residue 235, skipping most of the 489 amino acids encoded by the wild-type transcript. Western blot showed the complete absence of wild-type protein in skeletal muscle.
(J:92821)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Prkag3 Mutation: |
26 strains or lines available
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Original: |
J:92821 Barnes BR, et al., The 5'-AMP-activated protein kinase gamma3 isoform has a key role in carbohydrate and lipid metabolism in glycolytic skeletal muscle. J Biol Chem. 2004 Sep 10;279(37):38441-7 |
All: |
14 reference(s) |
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