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Targeted Allele Detail
Symbol: Ppargtm1Uls
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, Beatrice Desvergne
MGI ID: MGI:3055128
Synonyms: PPARG-
Gene: Pparg  Location: Chr6:115360951-115490399 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Germline Transmission:  Earliest citation of germline transmission: J:92826
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1, containing the translational start site of the Pparg1 isoform, and part of exon 2, encoding the first zinc finger of the DNA binding domain, were replaced with a PGK-neo cassette. Both isoform 1 and 2 were disrupted by this event, as shown by lack of protein in Western blot of white adipose tissue. (J:92826)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  23 strains or lines available
Original:  J:92826 Rieusset J, et al., Altered growth in male peroxisome proliferator-activated receptor gamma (PPARgamma) heterozygous mice: involvement of PPARgamma in a negative feedback regulation of growth hormone action. Mol Endocrinol. 2004 Oct;18(10):2363-77
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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