Tnfsf8^tm1Pod
Targeted Allele Detail

Summary

• Symbol: Tnfsf8^tm1Pod
• Name: tumor necrosis factor (ligand) superfamily, member 8; targeted mutation 1, Eckhard Podack
• MGI ID: MGI:3054968
• Synonyms: CD153^-, CD30L^-, Tnfsf8^tm1Blaz
• Gene: Tnfsf8 Location: Chr4:63749545-63779584 bp, - strand Genetic Position: Chr4, 34.06 cM
• Alliance: Tnfsf8^tm1Pod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92723
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace 594 bp, including exon 1, with a neo cassette. RT-PCR of spleen cells shows absence of wild-type transcript in mutant mice. (J:92723)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfsf8 Mutation: 20 strains or lines available

References

• Original: J:92723 Blazar BR, et al., CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. J Immunol. 2004 Sep 1;173(5):2933-41
• All: 11 reference(s)