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Tnfsf8tm1Pod
Targeted Allele Detail
Nomenclature
Symbol: Tnfsf8tm1Pod
Name: tumor necrosis factor (ligand) superfamily, member 8; targeted mutation 1, Eckhard Podack
MGI ID: MGI:3054968
Synonyms: CD153-, CD30L-, Tnfsf8tm1Blaz
Gene: Tnfsf8  Location: Chr4:63831308-63861347 bp, - strand  Genetic Position: Chr4, 34.06 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92723
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace 594 bp, including exon 1, with a neo cassette. RT-PCR of spleen cells shows absence of wild-type transcript in mutant mice. (J:92723)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfsf8 Mutation:  9 strains or lines available
References
Original:  J:92723 Blazar BR, et al., CD30/CD30 ligand (CD153) interaction regulates CD4+ T cell-mediated graft-versus-host disease. J Immunol. 2004 Sep 1;173(5):2933-41
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory