Gabpa^Gt(XH074)Byg
Gene trapped Allele Detail

Summary

• Symbol: Gabpa^Gt(XH074)Byg
• Name: GA repeat binding protein, alpha; gene trap XH074, BayGenomics
• MGI ID: MGI:3054951
• Synonyms: Gabpa^{Gt(pGT1Lxf)1Wjl}, Gabpa^tp
• Gene: Gabpa Location: Chr16:84631813-84660667 bp, + strand Genetic Position: Chr16, 46.92 cM, cytoband C3-4
• Alliance: Gabpa^Gt(XH074)Byg page

Mutation origin

• Mutant Cell Line: XH074
• Germline Transmission: Earliest citation of germline transmission: J:92671
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1Lxf Vector Type: gene trap
• Mutation details: XH074 ES cells contain an insertion of Beta-galactosidase-encoding vector pGT1Lxf in intron V of Gapba. ES cells were injected into C57BL/6 blastocysts. (J:92671)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XH074	CC199554 ; (MGI Seq Detail)	5' RACE	Chr16:84638317-84643255 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  82 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	17 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabpa Mutation: 66 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:92671 Xue HH, et al., GA binding protein regulates interleukin 7 receptor alpha-chain gene expression in T cells. Nat Immunol. 2004 Oct;5(10):1036-44
• All: 4 reference(s)