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Rassf5tm1Kina
Targeted Allele Detail
Nomenclature
Symbol: Rassf5tm1Kina
Name: Ras association (RalGDS/AF-6) domain family member 5; targeted mutation 1, Tatsuo Kinashi
MGI ID: MGI:3054868
Synonyms: RAPL-
Gene: Rassf5  Location: Chr1:131176410-131245178 bp, - strand  Genetic Position: Chr1, 56.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92670
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette (pLNTK) replaced exon 1 in the gene, including the initiation methionine of the protein. Northern blot analysis of spleen showed no detectable mRNA. Immunoblot analysis of spleen and thymus did not detect protein. (J:92670)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rassf5 Mutation:  0 strains or lines available
References
Original:  J:92670 Katagiri K, et al., Crucial functions of the Rap1 effector molecule RAPL in lymphocyte and dendritic cell trafficking. Nat Immunol. 2004 Oct;5(10):1045-51
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory