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Ptpn13tm1Wjh
Targeted Allele Detail
Nomenclature
Symbol: Ptpn13tm1Wjh
Name: protein tyrosine phosphatase, non-receptor type 13; targeted mutation 1, Wiljan Hendriks
MGI ID: MGI:3054733
Synonyms: PTP-BLdeltaP/deltaP, Ptpn13deltaPTP
Gene: Ptpn13  Location: Chr5:103425192-103598303 bp, + strand  Genetic Position: Chr5, 50.43 cM, cytoband E-F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92590
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 42 to 46 were replaced with a neomycin resistance cassette. Northern blot analysis demonstrated that a truncated mRNA was produced which was shorter than normal by 961 bases. The truncated mRNA lacked sequence coding for the catalytic part of the protein. (J:92590)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptpn13 Mutation:  59 strains or lines available
References
Original:  J:92590 Wansink DG, et al., Mild impairment of motor nerve repair in mice lacking PTP-BL tyrosine phosphatase activity. Physiol Genomics. 2004 Sep 16;19(1):50-60
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory