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Tg(DM15)26Bew
Transgene Detail
Nomenclature
Symbol: Tg(DM15)26Bew
Name: transgene insertion 26, Be Wieringa
MGI ID: MGI:3054417
Transgene: Tg(DM15)26Bew  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(DM15)26Bew expresses 1 gene
 
Mutation detailsThis transgene contains a 14 kb genomic fragment including all of the human DM15 gene and the last exon from the upstream gene DMWD. Two founder lines were generated Tg26 and Tg15 with 25 and 20 copies of the transgene integrated, respectively. Expression is seen in the muscle and smooth muscle containing tissues. Tg26 has a higher level of expression and more severe phenotype compared to Tg15 which has lower expression and a milder version of the same phenotype seen in Tg26. (J:33711)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Younger mice do not exhibit typical symptoms of Dystrophia Myotonica 1 (J:33711), however older mice (11-15 months of age) develop the distinctive traits of Dystrophia Myotonica 1 (J:93614).

References
Original:  J:33711 Jansen G, et al., Abnormal myotonic dystrophy protein kinase levels produce only mild myopathy in mice [see comments]. Nat Genet. 1996 Jul;13(3):316-24
All:  2 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/24/2015
MGI 5.21
The Jackson Laboratory