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Prnptm1Ito
Targeted Allele Detail
Nomenclature
Symbol: Prnptm1Ito
Name: prion protein; targeted mutation 1, Shigeyoshi Itohara
MGI ID: MGI:3054245
Synonyms: Prnp-, Prnp0, Rikn Prnp-
Gene: Prnp  Location: Chr2:131909928-131938429 bp, + strand  Genetic Position: Chr2, 64.07 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68801
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance cassette replaced the gene open reading frame and the 3' end of intron 2. Western analysis of lysates from cerebra did not detect protein. (J:68801)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Prnp Mutation:  89 strains or lines available
References
Original:  J:68801 Yokoyama T, et al., In vivo conversion of cellular prion protein to pathogenic isoforms, as monitored by conformation-specific antibodies. J Biol Chem. 2001 Apr 6;276(14):11265-71
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory