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Tg(Vil-cre/ERT2)23Syr
Transgene Detail
Nomenclature
Symbol: Tg(Vil-cre/ERT2)23Syr
Name: transgene insertion 23, Sylvie Robine
MGI ID: MGI:3053826
Synonyms: TgvCreERT2, Tg(Vil-cre/ESR1)23Syr, vil-Cre-ERT2, vil-Cre-ERT2, villin::CreERT2, Villin-Cre(ER-T2), Villin-CreERT2
Transgene: Tg(Vil-cre/ERT2)23Syr  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6 x DBA/2)
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    induced by tamoxifen
Mutation:    Insertion
 
Mutation detailsA 9 kb segment of the regulatory region of the mouse Vil gene drives expression of cre recombinase fused to a mutated ligand binding domain of the human estrogen receptor. Cre recombination is inducible with tamoxifen treatment in epithelial cells all along the crypt-villus axis and in undifferentiated progenitor cells in the crypt region. This is a representative record for the two lines generated (Fo23 and Fo24) that have the same inducible expression pattern. Only 1 copy of the transgene integrated in these lines. (J:92295)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Vil1     Summary of all recombinase alleles driven by Vil1.
 

Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:92295 el Marjou F, et al., Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis. 2004 Jul;39(3):186-93
All:  104 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory