Tnxb^tm1Kmat
Targeted Allele Detail

Summary

• Symbol: Tnxb^tm1Kmat
• Name: tenascin XB; targeted mutation 1, Ken-ichi Matsumoto
• MGI ID: MGI:3053791
• Synonyms: Tnx^-
• Gene: Tnxb Location: Chr17:34879431-34938789 bp, + strand Genetic Position: Chr17, 18.24 cM
• Alliance: Tnxb^tm1Kmat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92581
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, containing the ATG, was replaced by a PGK-neo. Southern blot confirmed recombination in ES cells. Western blot of mutant hearts indicated absence of protein. (J:92581)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tnxb Mutation: 183 strains or lines available

References

• Original: J:92581 Matsumoto K, et al., Tumour invasion and metastasis are promoted in mice deficient in tenascin-X. Genes Cells. 2001 Dec;6(12):1101-11
• All: 13 reference(s)