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Tnxbtm1Kmat
Targeted Allele Detail
Nomenclature
Symbol: Tnxbtm1Kmat
Name: tenascin XB; targeted mutation 1, Ken-ichi Matsumoto
MGI ID: MGI:3053791
Synonyms: Tnx-
Gene: Tnxb  Location: Chr17:34670535-34719815 bp, + strand  Genetic Position: Chr17, 18.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92581
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2, containing the ATG, was replaced by a PGK-neo. Southern blot confirmed recombination in ES cells. Western blot of mutant hearts indicated absence of protein. (J:92581)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Tnxb Mutation:  91 strains or lines available
References
Original:  J:92581 Matsumoto K, et al., Tumour invasion and metastasis are promoted in mice deficient in tenascin-X. Genes Cells. 2001 Dec;6(12):1101-11
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory