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Plscr3tm1Sims
Targeted Allele Detail
Nomenclature
Symbol: Plscr3tm1Sims
Name: phospholipid scramblase 3; targeted mutation 1, Peter J Sims
MGI ID: MGI:3053448
Synonyms: PLSCR3-, Plscr3Gt(Betageo)1Sims
Gene: Plscr3  Location: Chr11:69846376-69851043 bp, + strand  Genetic Position: Chr11, 42.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92404
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA gene trap vector containing pKOS-lacZ/MC1neo (Lexicon Genetics, Woodlands, TX) was inserted to replace the first four exons of the gene. Western blot analysis on platelets, lung, muscle and adipocytes did not detect protein. (J:92404)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plscr3 Mutation:  12 strains or lines available
Notes
ES cell line derived from 129S/SvEvBrd.
References
Original:  J:92404 Wiedmer T, et al., Adiposity, dyslipidemia, and insulin resistance in mice with targeted deletion of phospholipid scramblase 3 (PLSCR3). Proc Natl Acad Sci U S A. 2004 Sep 7;101(36):13296-301
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory