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Ly96tm1Kmiy
Targeted Allele Detail
Nomenclature
Symbol: Ly96tm1Kmiy
Name: lymphocyte antigen 96; targeted mutation 1, Kensuke Miyake
MGI ID: MGI:3053109
Synonyms: Ly96-, Md2-, MD-2-
Gene: Ly96  Location: Chr1:16688456-16709605 bp, + strand  Genetic Position: Chr1, 5.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92494
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace the first exon, encoding 37 amino acids, with a neomycin resistance gene. RT-PCR indicated homozygotes lacked mRNA in bone marrow-derived macrophages. Protein was not expressed on the cell surface as shown by staining with a mAB for the TLR4-Ly96 complex. (J:92494)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ly96 Mutation:  9 strains or lines available
References
Original:  J:92494 Nagai Y, et al., Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat Immunol. 2002 Jul;3(7):667-72
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory