About   Help   FAQ
Targeted Allele Detail
Symbol: Fgfr2tm4Lni
Name: fibroblast growth factor receptor 2; targeted mutation 4, Peter Lonai
MGI ID: MGI:3053095
Synonyms: Fgfr2cC342Y
Gene: Fgfr2  Location: Chr7:130162451-133123350 bp, - strand  Genetic Position: Chr7, 73.19 cM
+/+ wildtype and Fgfr2tm4Lni/+ skull phenotypes and histological sections.

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:92433
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
Mutation detailsA C342Y replacement was inserted into exon 9 (the IIIc exon) and a floxed neo into intron 9. Mating with mice expressing cre in the germ line excised the floxed neo. (J:92433)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Fgfr2 Mutation:  20 strains or lines available
Original:  J:92433 Eswarakumar VP, et al., A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12555-60
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.01
The Jackson Laboratory