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Noboxtm1Rajk
Targeted Allele Detail
Nomenclature
Symbol: Noboxtm1Rajk
Name: NOBOX oogenesis homeobox; targeted mutation 1, Aleksandar Rajkovic
MGI ID: MGI:3053093
Synonyms: Nobox-
Gene: Nobox  Location: Chr6:43303674-43309554 bp, - strand  Genetic Position: Chr6, 21.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92421
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace part of exon 2 and all of exons 3-8, encoding the homeodomain and including the polyadenylation signal, with a Pgk1-HPRT cassette. Southern blot and multiplex PCR confirmed recombination in mice. (J:92421)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 3 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nobox Mutation:  14 strains or lines available
References
Original:  J:92421 Rajkovic A, et al., NOBOX deficiency disrupts early folliculogenesis and oocyte-specific gene expression. Science. 2004 Aug 20;305(5687):1157-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory