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Ceacam1Hv2-r
Spontaneous Allele Detail
Nomenclature
Symbol: Ceacam1Hv2-r
Name: carcinoembryonic antigen-related cell adhesion molecule 1; hepatitis virus (MHV-4) resistance
MGI ID: MGI:3053078
Synonyms: Ceacam1b
Gene: Ceacam1  Location: Chr7:25461707-25477603 bp, - strand  Genetic Position: Chr7, 13.84 cM
Mutation
origin
Strain of Origin:  SJL/J
Mutation
description
Allele Type:    Spontaneous
Mutation:    Other
 
Mutation detailsThis allele determines resistance to infection by the A59 strains of mouse hepatitis virus MHV-4, and is found only in the SJL/J strain. The protein encoded by this allele differs in the first 27 of the 108 amino acids of the first Ig domain compared to the susceptible allele. This region is thought to be important for virus binding. (J:3241, J:92495)
Inheritance:    Not Specified
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ceacam1 Mutation:  28 strains or lines available
Notes

Previously called Mhv-1, Hv2. This locus controls resistance of neurons and macrophages to infection by the JHM and A59 strains of mouse hepatitis virus MHV-4. The allele Ceacam1Hv2-r determines resistance and has been found only in the SJL/J strain; the strains A/J, C57BL/10, BALB/c, NZB, DBA/2, AKR/J, CBA/J, C3H/He, and SWR are all susceptible to infection (Ceacam1Hv2-s. Heterozygotes are fully susceptible (J:6451, J:14870, J:7456).

References
Original:  J:701 Dveksler GS, et al., Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. J Virol. 1991 Dec;65(12):6881-91
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory