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Targeted Allele Detail
Symbol: Ceacam1tm2Bcn
Name: CEA cell adhesion molecule 1; targeted mutation 2, Nicole Beauchemin
MGI ID: MGI:3053071
Synonyms: 11H11, 2D2, Cc1-, Ceacam1a-
Gene: Ceacam1  Location: Chr7:25161132-25177028 bp, - strand  Genetic Position: Chr7, 13.84 cM
Germline Transmission:  Earliest citation of germline transmission: J:92376
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced the first two exons of the gene. These exons contain the ATG and encode the first Ig-like domain. RT-PCR confirmed absence of transcript in mutants. Western blot analysis on colon and liver did not detect protein. Northern blot analysis on colon and liver did not detect transcript. (J:92376, J:115838)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ceacam1 Mutation:  30 strains or lines available
Original:  J:92376 Hemmila E, et al., Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus a59. J Virol. 2004 Sep;78(18):10156-65
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory