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Ceacam1tm2Bcn
Targeted Allele Detail
Nomenclature
Symbol: Ceacam1tm2Bcn
Name: carcinoembryonic antigen-related cell adhesion molecule 1; targeted mutation 2, Nicole Beauchemin
MGI ID: MGI:3053071
Synonyms: 11H11, 2D2, Cc1-, Ceacam1a-
Gene: Ceacam1  Location: Chr7:25461707-25477603 bp, - strand  Genetic Position: Chr7, 13.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92376
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the first two exons of the gene. These exons contain the ATG and encode the first Ig-like domain. RT-PCR confirmed absence of transcript in mutants. Western blot analysis on colon and liver did not detect protein. Northern blot analysis on colon and liver did not detect transcript. (J:92376, J:115838)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ceacam1 Mutation:  15 strains or lines available
References
Original:  J:92376 Hemmila E, et al., Ceacam1a-/- mice are completely resistant to infection by murine coronavirus mouse hepatitis virus a59. J Virol. 2004 Sep;78(18):10156-65
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory