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Targeted Allele Detail
Symbol: Mapk8ip3tm1Rjd
Name: mitogen-activated protein kinase 8 interacting protein 3; targeted mutation 1, Roger J Davis
MGI ID: MGI:3053053
Synonyms: Jip3-
Gene: Mapk8ip3  Location: Chr17:25116480-25155951 bp, - strand  Genetic Position: Chr17, 12.53 cM
Germline Transmission:  Earliest citation of germline transmission: J:85160
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1 was replaced by a neomycin resistance cassette. Northern blot analysis demonstrated the loss of the transcript. This was confirmed by immunoblot analysis demonstrating the loss of the protein. (J:85160)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 50 assay results
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mapk8ip3 Mutation:  33 strains or lines available
Original:  J:85160 Kelkar N, et al., Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9843-8
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory