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Tbxas1tm1Swl
Targeted Allele Detail
Nomenclature
Symbol: Tbxas1tm1Swl
Name: thromboxane A synthase 1, platelet; targeted mutation 1, Shu-Wha Lin
MGI ID: MGI:3052866
Synonyms: TXAS-
Gene: Tbxas1  Location: Chr6:38875404-39084585 bp, + strand  Genetic Position: Chr6, 17.85 cM, cytoband F1-pter
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90922
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encoding amino acids 234-333 and the first 233 bp of intron 9 were replaced with an HPRT cassette. Southern blot and PCR using tail DNA confirmed recombination. Northern blot and RT-PCR showed lack of wild-type transcript in spleen and thymus tissues of mutants. (J:90922)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbxas1 Mutation:  17 strains or lines available
References
Original:  J:90922 Yu IS, et al., TXAS-deleted mice exhibit normal thrombopoiesis, defective hemostasis, and resistance to arachidonate-induced death. Blood. 2004 Jul 1;104(1):135-42
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory