Hnf4a^tm1(cre)Sdv
Targeted Allele Detail

Summary

• Symbol: Hnf4a^tm1(cre)Sdv
• Name: hepatic nuclear factor 4, alpha; targeted mutation 1, Stephane D Vincent
• MGI ID: MGI:3052820
• Synonyms: HNF4alphaCre, Hnf4alpha^Creex2
• Gene: Hnf4a Location: Chr2:163348731-163414827 bp, + strand Genetic Position: Chr2, 84.32 cM
• Alliance: Hnf4a^tm1(cre)Sdv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:92294
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Hnf4a^tm1(cre)Sdv expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Hnf4a (MGI:109128)

• Mutation details: An IRES-cre-FRT-pgk-hygro-FRT cassette was inserted into exon 2. Crossing with Flp expressing mice excised the pgk-hygro sequences. PCR confirmed recombination in mice. Cre expression mirrored expression of the endogenous gene. (J:92294)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Hnf4a (mouse) Summary of all recombinase alleles driven by Hnf4a. Comparative matrix view of recombinase activities Alliance mouse Hnf4a gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hnf4a Mutation: 27 strains or lines available

References

• Original: J:92294 Vincent SD, et al., Targeted insertion of an IRES Cre into the Hnf4alpha locus: Cre-mediated recombination in the liver, kidney, and gut epithelium. Genesis. 2004 Jul;39(3):206-11
• All: 2 reference(s)