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Aadattm1Tag
Targeted Allele Detail
Nomenclature
Symbol: Aadattm1Tag
Name: aminoadipate aminotransferase; targeted mutation 1, Danilo A Tagle
MGI ID: MGI:3052711
Synonyms: mKat-2-
Gene: Aadat  Location: Chr8:60505932-60545677 bp, + strand  Genetic Position: Chr8, 30.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92240
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 was replaced by a PGK-neo in reverse orientation, resulting in a frameshift downstream of the targeted region. Southern blot and PCR confirmed recombination. Northern blot showed no transcript in mutants and Western blot showed no protein was translated in mutant kidneys. (J:92240)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aadat Mutation:  22 strains or lines available
References
Original:  J:92240 Yu P, et al., Biochemical and phenotypic abnormalities in kynurenine aminotransferase II-deficient mice. Mol Cell Biol. 2004 Aug;24(16):6919-30
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/23/2021
MGI 6.16
The Jackson Laboratory