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Targeted Allele Detail
Symbol: Mknk1tm1Fuku
Name: MAP kinase-interacting serine/threonine kinase 1; targeted mutation 1, Rikiro Fukunaga
MGI ID: MGI:3052673
Synonyms: Mnk1-
Gene: Mknk1  Location: Chr4:115839198-115879250 bp, + strand  Genetic Position: Chr4, 53.06 cM
Germline Transmission:  Earliest citation of germline transmission: J:92274
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 5 and 6 were replaced with a neomycin resistance gene. Southern blot confirmed recombination and Western blot of mutant spleen demonstrated a lack of protein. (J:92274)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Mknk1 Mutation:  5 strains or lines available
Original:  J:92274 Ueda T, et al., Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol. 2004 Aug;24(15):6539-49
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
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