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Tg(CAG-lacZ-WGA)330Bbm
Transgene Detail
Nomenclature
Symbol: Tg(CAG-lacZ-WGA)330Bbm
Name: transgene insertion 330, Allan Basbaum
MGI ID: MGI:3052324
Synonyms: Tg(ACTB-lacZ-WGA)330Bbm, Tg(CAG-lacZ-WGA)330Bbm, ZW, ZW19
Transgene: Tg(CAG-lacZ-WGA)330Bbm  Location: unknown  
Transgene
origin
Strain of Origin:  (C57BL/6J x CBA/J)F1
Transgene
description
Transgene Type:    Transgenic (Reporter)
Mutation:    Insertion
 
Mutation detailsThe transgene is comprised of a minimal immediate-early CMV enhancer/chicken beta-actin promoter driving ubiquitous expression of a lox-P flanked beta-galactosidase/neomycin phosphotransferase II (beta-geo) fusion gene that terminates in a strong, triple polyadenylation signal, followed by a C-terminally truncated wheat germ agglutinin coding sequence. Neuron-specific excision of the beta-geo gene by cre recombinase permits expression of the lectin, whose migration allows tracing of synapses involving the expressing cells. (J:92042)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Of three transgenic lines generated - called ZW5, ZW16 and ZW19 by Braz and colleagues (2002) - only ZW19, which exhibited the highest transmission rates, was propagated.
References
Original:  J:92042 Braz JM, et al., Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic mice. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):15148-53
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory