About   Help   FAQ
Hrtm1Cct
Targeted Allele Detail
Nomenclature
Symbol: Hrtm1Cct
Name: hairless; targeted mutation 1, Catherine C Thompson
MGI ID: MGI:3052135
Synonyms: Hr-
Gene: Hr  Location: Chr14:70552212-70573548 bp, + strand  Genetic Position: Chr14, 36.32 cM
Characterization of the Hrtm1Cct/Hrtm1Cct mouse

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92053
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 8-10 were replaced with a floxed PGK-neo cassette. Southern blot confirmed recombination in mutant mice. Northern blot of mutant skin indicated lack of full-length mRNA and Western blot showed a lack of full-length protein in the skin of mutants. (J:92053)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hr Mutation:  28 strains or lines available
References
Original:  J:92053 Zarach JM, et al., The co-repressor hairless has a role in epithelial cell differentiation in the skin. Development. 2004 Sep;131(17):4189-200
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory