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Disp1tm1Amc
Targeted Allele Detail
Nomenclature
Symbol: Disp1tm1Amc
Name: dispatched homolog 1 (Drosophila); targeted mutation 1, Andrew P McMahon
MGI ID: MGI:3052133
Synonyms: Disp1delta2
Gene: Disp1  Location: Chr1:183086266-183221522 bp, - strand  Genetic Position: Chr1, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:92058
Parent Cell Line:  AV3 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Hypomorph, Modified isoform(s))
Mutation:    Intragenic deletion
 
Mutation detailsA targeting vector was designed to flank exon 2, containing an initiation site and N-terminal 168 amino acids, with loxP sites. Cre expression in the germ line excised exon 2, leaving a single loxP site. Analysis of transcripts suggests that, in the absence of exon 2, exon 1B was replaced by exon 1A, which was spliced to exon 3, thereby allowing translation from an initiation codon in exon 4. The result was a N-terminal truncated transcript. Southern blot confirmed absence of exon 2 in mutant mice with this putatively hypomorphic allele. (J:92058)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Disp1 Mutation:  1 strain or line available
References
Original:  J:92058 Tian H, et al., Dose dependency of Disp1 and genetic interaction between Disp1 and other hedgehog signaling components in the mouse. Development. 2004 Aug;131(16):4021-33
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory