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Krt12tm1Wwk
Targeted Allele Detail
Nomenclature
Symbol: Krt12tm1Wwk
Name: keratin 12; targeted mutation 1, Winston W Y Kao
MGI ID: MGI:3051854
Gene: Krt12  Location: Chr11:99415666-99422259 bp, - strand  Genetic Position: Chr11, 62.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38023
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3-7 and intron 7 were replaced with a neomycin resistance gene. Immunohistochemistry, Western blot, Northern blot and in situ hybridization confirmed lack of gene expression. (J:38023)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Krt12 Mutation:  2 strains or lines available
References
Original:  J:38023 Kao WW, et al., Keratin 12-deficient mice have fragile corneal epithelia. Invest Ophthalmol Vis Sci. 1996 Dec;37(13):2572-84
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory