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Targeted Allele Detail
Symbol: Ptprn2tm1Aln
Name: protein tyrosine phosphatase, receptor type, N polypeptide 2; targeted mutation 1, Abner Louis Notkins
MGI ID: MGI:3051779
Synonyms: IA-2Beta-
Gene: Ptprn2  Location: Chr12:116485720-117276849 bp, + strand  Genetic Position: Chr12, 62.65 cM, cytoband F
Germline Transmission:  Earliest citation of germline transmission: J:91889
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance gene replaced part of the 5' upstream promoter, exon 1 and part of intron 1, including the AUG start codon, 106 additional codons and a 5' UTR of at least 145 nucleotides. Northern blot indicated absence of transcript in brains of mutant mice. Further confirmation was provided by Western blot analysis showing lack of wild-type protein in brains of mutant mice. (J:91889)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptprn2 Mutation:  40 strains or lines available
Original:  J:91889 Kubosaki A, et al., Targeted disruption of the IA-2beta gene causes glucose intolerance and impairs insulin secretion but does not prevent the development of diabetes in NOD mice. Diabetes. 2004 Jul;53(7):1684-91
All:  9 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.07
The Jackson Laboratory