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Cnptm1(cre)Kan
Targeted Allele Detail
Nomenclature
Symbol: Cnptm1(cre)Kan
Name: 2',3'-cyclic nucleotide 3' phosphodiesterase; targeted mutation 1, Klaus-Armin Nave
MGI ID: MGI:3051635
Synonyms: Cnp1Cre, CNPcre, CNP-Cre, CNP/Cre
Gene: Cnp  Location: Chr11:100574909-100591418 bp, + strand  Genetic Position: Chr11, 63.47 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91814
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
 
Mutation detailsThe entire coding region was replaced with a Cre-PGKpuro cassette. RT-PCR indicated lack of endogenous transcript and presence of Cre in mutants. Western blot confirmed that no endogenous protein was present in mutant brain lysates. (J:91814)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Cnp     Summary of all recombinase alleles driven by Cnp. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnp Mutation:  19 strains or lines available
References
Original:  J:91814 Lappe-Siefke C, et al., Disruption of Cnp1 uncouples oligodendroglial functions in axonal support and myelination. Nat Genet. 2003 Mar;33(3):366-74
All:  127 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory