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Hprt1tm1(Ggt1-Agtr1)Cof
Targeted Allele Detail
Summary
Symbol: Hprt1tm1(Ggt1-Agtr1)Cof
Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Thomas M Coffman
MGI ID: MGI:3051543
Synonyms: Gamma-GT-AT1A
Gene: Hprt1  Location: ChrX:52077014-52110536 bp, + strand  Genetic Position: ChrX, 29.31 cM, cytoband A6
Alliance: Hprt1tm1(Ggt1-Agtr1)Cof page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91837
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Insertion
 
Hprt1tm1(Ggt1-Agtr1)Cof expresses 1 gene
 
Mutation detailsA vector containing the P1 portion of the promoter from the rat Ggtp gene, mouse Agtr1a and the pA signal, as well as the human HPRT promoter, exon 1 and mouse Hprt exon 2 was inserted into ES cells with a deletion proximal to exon 3. Southern blot analysis confirmed recombination in ES cells. RT-PCR showed that the inserted sequence was expressed in transgenic kidneys. (J:91837)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hprt1 Mutation:  1272 strains or lines available
References
Original:  J:91837 Le TH, et al., A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiol Genomics. 2004 Aug 11;18(3):290-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory