Hoxd11^tm2Ddu
Targeted Allele Detail

Summary

• Symbol: Hoxd11^tm2Ddu
• Name: homeobox D11; targeted mutation 2, Denis Duboule
• MGI ID: MGI:3051381
• Synonyms: Hoxd-11^RVIIIGe1
• Gene: Hoxd11 Location: Chr2:74509902-74517360 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd11^tm2Ddu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:41828
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The RVIII region was deleted and replaced with an FRT sequence and a loxP flanked PGK-neo in reverse transcriptional orientation about 700 bp downstream of the deleted sequence. Southern blotting verified correct recombination. (J:41828)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd11 Mutation: 14 strains or lines available

References

• Original: J:41828 Zakany J, et al., Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. EMBO J. 1997 Jul 16;16(14):4393-402
• All: 2 reference(s)