About   Help   FAQ
Hoxd11tm2Ddu
Targeted Allele Detail
Nomenclature
Symbol: Hoxd11tm2Ddu
Name: homeobox D11; targeted mutation 2, Denis Duboule
MGI ID: MGI:3051381
Synonyms: Hoxd-11RVIIIGe1
Gene: Hoxd11  Location: Chr2:74679557-74687016 bp, + strand  Genetic Position: Chr2, 44.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41828
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe RVIII region was deleted and replaced with an FRT sequence and a loxP flanked PGK-neo in reverse transcriptional orientation about 700 bp downstream of the deleted sequence. Southern blotting verified correct recombination. (J:41828)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd11 Mutation:  2 strains or lines available
References
Original:  J:41828 Zakany J, et al., Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. EMBO J. 1997 Jul 16;16(14):4393-402
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/13/2017
MGI 6.11
The Jackson Laboratory