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Hoxd11tm2Ddu
Targeted Allele Detail
Nomenclature
Symbol: Hoxd11tm2Ddu
Name: homeobox D11; targeted mutation 2, Denis Duboule
MGI ID: MGI:3051381
Synonyms: Hoxd-11RVIIIGe1
Gene: Hoxd11  Location: Chr2:74679557-74687016 bp, + strand  Genetic Position: Chr2, 44.13 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:41828
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe RVIII region was deleted and replaced with an FRT sequence and a loxP flanked PGK-neo in reverse transcriptional orientation about 700 bp downstream of the deleted sequence. Southern blotting verified correct recombination. (J:41828)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxd11 Mutation:  0 strains or lines available
References
Original:  J:41828 Zakany J, et al., Deletion of a HoxD enhancer induces transcriptional heterochrony leading to transposition of the sacrum. EMBO J. 1997 Jul 16;16(14):4393-402
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory