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Ptcratm1Vbo
Targeted Allele Detail
Nomenclature
Symbol: Ptcratm1Vbo
Name: pre T cell antigen receptor alpha; targeted mutation 1, Harald von Boehmer
MGI ID: MGI:3051255
Synonyms: pTalpha-
Gene: Ptcra  Location: Chr17:46755663-46763712 bp, - strand  Genetic Position: Chr17, 22.9 cM, cytoband D-E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:26493
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 and 4, which encode the connecting peptide, the transmembrane region, the cytoplasmic tail, and most of the 3' UTR were replaced with a neo cassette. Correct recombination was confirmed by Southern blot. (J:26493)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptcra Mutation:  11 strains or lines available
References
Original:  J:26493 Fehling HJ, et al., Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Nature. 1995 Jun 29;375(6534):795-8
All:  46 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory