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Rabgef1tm2Glli
Targeted Allele Detail
Nomenclature
Symbol: Rabgef1tm2Glli
Name: RAB guanine nucleotide exchange factor (GEF) 1; targeted mutation 2, Stephen J Galli
MGI ID: MGI:3051238
Synonyms: Rabgef1-
Gene: Rabgef1  Location: Chr5:130171798-130214342 bp, + strand  Genetic Position: Chr5, 68.78 cM, cytoband F
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91790
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  WBB6F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Disruption caused by insertion of vector
 
Mutation detailsExon 2 was replaced with an IRES and floxed PGK-neo cassette. Southern blot confirmed recombination and RT-PCR indicated no mRNA in mutant pups. Immunoblot demonstrated lack of expression of the full-length protein in fetal liver mast cells. (J:91790)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rabgef1 Mutation:  53 strains or lines available
References
Original:  J:91790 Tam SY, et al., RabGEF1 is a negative regulator of mast cell activation and skin inflammation. Nat Immunol. 2004 Aug;5(8):844-52
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory