Efnb2^tm1Henk
Targeted Allele Detail

Summary

• Symbol: Efnb2^tm1Henk
• Name: ephrin B2; targeted mutation 1, Mark Henkemeyer
• MGI ID: MGI:3051214
• Synonyms: B2^lacZ, EB2/LZ, ephrin2^lacZ, Ephrin-B2^lacZ
• Gene: Efnb2 Location: Chr8:8667434-8711242 bp, - strand Genetic Position: Chr8, 3.42 cM
• Alliance: Efnb2^tm1Henk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91491
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence encoding most of the cytoplasmic domain (amino acids 264-336) was replaced with an in-frame floxed lacZ cassette, and an frt-flanked PGK-neo. X-gal staining demonstrated LacZ was expressed in mutants. (J:91491)

Expression

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efnb2 Mutation: 28 strains or lines available

References

• Original: J:91491 Dravis C, et al., Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. Dev Biol. 2004 Jul 15;271(2):272-90
• All: 27 reference(s)