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Targeted Allele Detail
Symbol: Cyb5r4tm1Hfb
Name: cytochrome b5 reductase 4; targeted mutation 1, H Franklin Bunn
MGI ID: MGI:3050973
Synonyms: Ncb5or-
Gene: Cyb5r4  Location: Chr9:86904067-86959827 bp, + strand  Genetic Position: Chr9, 46.69 cM
Immunohistochemical and ultrastructural assessment of insulin- and glucagon-producing cells in Cyb5r4tm1Hfb/Cyb5r4tm1Hfb mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:91486
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 4, which contains sequence encoding the heme-binding domain, was replaced with a PGK-hygromycin gene. Mutant mice did not express full length mRNA or protein, as shown by Northern blot and Western blot, respectively. (J:91486)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Cyb5r4 Mutation:  33 strains or lines available
Original:  J:91486 Xie J, et al., Absence of a reductase, NCB5OR, causes insulin-deficient diabetes. Proc Natl Acad Sci U S A. 2004 Jul 20;101(29):10750-5
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory