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Tg(MMTV-Erbb2)NK1Mul
Transgene Detail
Nomenclature
Symbol: Tg(MMTV-Erbb2)NK1Mul
Name: transgene insertion NK1, William Muller
MGI ID: MGI:3050871
Synonyms: HER-2/neu, MMTV c-neu, MMTV-erbB2, MMTV-neu, MMTV-Tg.NK, Tg(MMTV-Erbb2)1Led, TG.NK
Transgene: Tg(MMTV-Erbb2)NK1Mul  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Tumor formation in transgenic mice is multifocal, stochastic, and matches the expression pattern of the transgene. While no transgene expression is detected at 5 and 8 weeks of age in normal mammary gland tissue, expression is detected in adenocarcinomas from older (23 week old) mice. 50% of transgenic mice derived from this founder line develop tumors within 6-12 months of age.

References
Original:  J:48632 Muller WJ, et al., Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 1988 Jul 1;54(1):105-15
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory