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Tg(MMTV-Erbb2)NK1Mul
Transgene Detail
Nomenclature
Symbol: Tg(MMTV-Erbb2)NK1Mul
Name: transgene insertion NK1, William Muller
MGI ID: MGI:3050871
Synonyms: HER-2/neu, MMTV c-neu, MMTV-erbB2, MMTV-neu, MMTV-Tg.NK, Tg(MMTV-Erbb2)1Led, TG.NK
Transgene: Tg(MMTV-Erbb2)NK1Mul  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MMTV-Erbb2)NK1Mul expresses 1 gene
 
Mutation detailsThis transgene contains the MMTV (mouse mammary tumor virus) LTR promoter, a 4.6 kb cDNA from the rat Erbb2 (avian erythroblastosis B2) oncogene, and an SV40 polyadenylation site sequence. The activated form of the rat gene is used in this construct, which differs from the wild-type allele by a point mutation, Val664Glu. Non-uniform and random transgene expression is detected by RNase protection assay in mammary gland epithelium from hemizygous transgenic mice. Six transgenic lines were produced (NA, NB, NF, NK, NL and NM). (J:48632)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Tumor formation in transgenic mice is multifocal, stochastic, and matches the expression pattern of the transgene. While no transgene expression is detected at 5 and 8 weeks of age in normal mammary gland tissue, expression is detected in adenocarcinomas from older (23 week old) mice. 50% of transgenic mice derived from this founder line develop tumors within 6-12 months of age.

References
Original:  J:48632 Muller WJ, et al., Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene. Cell. 1988 Jul 1;54(1):105-15
All:  62 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory