About   Help   FAQ
Targeted Allele Detail
Symbol: Dnajc5tm1Sud
Name: DnaJ heat shock protein family (Hsp40) member C5; targeted mutation 1, Thomas C Sudhof
MGI ID: MGI:3050763
Synonyms: CSP-, Cspa-, CSPalphaKO
Gene: Dnajc5  Location: Chr2:181518858-181552886 bp, + strand  Genetic Position: Chr2, 103.63 cM
Degenerating photoreceptor ribbon synapses in adult Dnajc5tm1Sud/Dnajc5tm1Sud mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:91702
Parent Cell Line:  SM1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 1, encoding residues 1-36, was replaced with a neomycin resistance gene. Immunoblot confirmed absence of protein in mutant brains. (J:91702)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dnajc5 Mutation:  20 strains or lines available
Original:  J:91702 Fernandez-Chacon R, et al., The synaptic vesicle protein CSP alpha prevents presynaptic degeneration. Neuron. 2004 Apr 22;42(2):237-51
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.14
The Jackson Laboratory