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Targeted Allele Detail
Symbol: Nr2c2tm1Chc
Name: nuclear receptor subfamily 2, group C, member 2; targeted mutation 1, Chawnshang Chang
MGI ID: MGI:3050563
Synonyms: Tr4-
Gene: Nr2c2  Location: Chr6:92091418-92173058 bp, + strand  Genetic Position: Chr6, 41.03 cM
Germline Transmission:  Earliest citation of germline transmission: J:91602
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA LacZ/MCI-neo cassette replaced most of exon 4 and all of exon 5. PCR, RT-PCR and Southern blot confirmed recombination and expression in homozygous mutants and decreased expression in heterozygotes. (J:91602)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr2c2 Mutation:  56 strains or lines available
Original:  J:91602 Mu X, et al., Targeted inactivation of testicular nuclear orphan receptor 4 delays and disrupts late meiotic prophase and subsequent meiotic divisions of spermatogenesis. Mol Cell Biol. 2004 Jul;24(13):5887-99
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory