Kcnk2^tm1Lzd
Targeted Allele Detail

Summary

• Symbol: Kcnk2^tm1Lzd
• Name: potassium channel, subfamily K, member 2; targeted mutation 1, Michel Lazdunski
• MGI ID: MGI:3050220
• Synonyms: Trek-1^-, TREK1^-, TREK-1 KO
• Gene: Kcnk2 Location: Chr1:188940127-189134470 bp, - strand Genetic Position: Chr1, 94.22 cM
• Alliance: Kcnk2^tm1Lzd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91531
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Crossing with mice ubiquitously expressing Cre recombinase, floxed exon 3 and a 3' neo were excised in the germ line. Exon 3 encodes the first transmembrane domain. PCR of testicular cDNA indicated that mutants expressed only a truncated transcript, shown by sequencing to be the result of the 311 deleted nucleotides from the targeted exon. (J:91531)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnk2 Mutation: 29 strains or lines available

References

• Original: J:91531 Heurteaux C, et al., TREK-1, a K(+) channel involved in neuroprotection and general anesthesia. EMBO J. 2004 Jul 7;23(13):2684-95
• All: 20 reference(s)