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Kcnk2tm1Lzd
Targeted Allele Detail
Nomenclature
Symbol: Kcnk2tm1Lzd
Name: potassium channel, subfamily K, member 2; targeted mutation 1, Michel Lazdunski
MGI ID: MGI:3050220
Synonyms: Trek-1-, TREK1-, TREK-1 KO
Gene: Kcnk2  Location: Chr1:189207930-189402273 bp, - strand  Genetic Position: Chr1, 94.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91531
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsCrossing with mice ubiquitously expressing Cre recombinase, floxed exon 3 and a 3' neo were excised in the germ line. Exon 3 encodes the first transmembrain domain. PCR of testicular cDNA indicated that mutants expressed only a truncated transcript, shown by sequencing to be the result of the 311 deleted nucleotides from the targeted exon. (J:91531)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnk2 Mutation:  1 strain or line available
References
Original:  J:91531 Heurteaux C, et al., TREK-1, a K(+) channel involved in neuroprotection and general anesthesia. EMBO J. 2004 Jul 7;23(13):2684-95
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory