Mus81^tm1Raz
Targeted Allele Detail

Summary

• Symbol: Mus81^tm1Raz
• Name: MUS81 structure-specific endonuclease subunit; targeted mutation 1, Razqallah Hakem
• MGI ID: MGI:3050210
• Synonyms: Mus81^deltaex3-4
• Gene: Mus81 Location: Chr19:5532589-5538461 bp, - strand Genetic Position: Chr19, 4.34 cM
• Alliance: Mus81^tm1Raz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91570
• Parent Cell Line: E14K (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 and 4 were replaced with a neomycin or hygromycin selectable cassette. ES cells with successful recombination were used to create a second targeted mutation. (J:91570)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mus81 Mutation: 29 strains or lines available

References

• Original: J:91570 McPherson JP, et al., Involvement of mammalian Mus81 in genome integrity and tumor suppression. Science. 2004 Jun 18;304(5678):1822-6
• All: 7 reference(s)