About   Help   FAQ
Btn1a1tm2Ihm
Targeted Allele Detail
Nomenclature
Symbol: Btn1a1tm2Ihm
Name: butyrophilin, subfamily 1, member A1; targeted mutation 2, Ian H Mather
MGI ID: MGI:3050156
Synonyms: BtnKO2
Gene: Btn1a1  Location: Chr13:23456992-23465901 bp, - strand  Genetic Position: Chr13, 9.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91440
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details1.28 kb of 5' flanking sequence, as well as the gene from exon 1A through the 5' region of exon 2 (nucleotides 2912 to 5654) were replaced with an iTLneo selection cassette. Southern blot confirmed recombination and Northern blot demonstrated lack of transcript in mutants. (J:91440)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btn1a1 Mutation:  9 strains or lines available
References
Original:  J:91440 Ogg SL, et al., Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10084-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/14/2017
MGI 6.08
The Jackson Laboratory