About   Help   FAQ
Btn1a1tm2Ihm
Targeted Allele Detail
Nomenclature
Symbol: Btn1a1tm2Ihm
Name: butyrophilin, subfamily 1, member A1; targeted mutation 2, Ian H Mather
MGI ID: MGI:3050156
Synonyms: BtnKO2
Gene: Btn1a1  Location: Chr13:23456992-23465901 bp, - strand  Genetic Position: Chr13, 9.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91440
Parent Cell Line:  iTL1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details1.28 kb of 5' flanking sequence, as well as the gene from exon 1A through the 5' region of exon 2 (nucleotides 2912 to 5654) were replaced with an iTLneo selection cassette. Southern blot confirmed recombination and Northern blot demonstrated lack of transcript in mutants. (J:91440)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Btn1a1 Mutation:  9 strains or lines available
References
Original:  J:91440 Ogg SL, et al., Expression of butyrophilin (Btn1a1) in lactating mammary gland is essential for the regulated secretion of milk-lipid droplets. Proc Natl Acad Sci U S A. 2004 Jul 6;101(27):10084-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory