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Targeted Allele Detail
Symbol: Ppargtm1Mae
Name: peroxisome proliferator activated receptor gamma; targeted mutation 1, Nobuyo Maeda
MGI ID: MGI:3050095
Synonyms: PPARgammaL, PPAR-gammaP465L, PpargP465L
Gene: Pparg  Location: Chr6:115361221-115490401 bp, + strand  Genetic Position: Chr6, 53.41 cM, cytoband E3-F1
Germline Transmission:  Earliest citation of germline transmission: J:91362
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Allele Type:    Targeted
Mutation:    Nucleotide substitutions
Mutation detailsA missense mutation was introduced to replace proline at position 465 in exon 6 with leucine. An ACN cassette containing a testis-specific Ace promoter, Cre recombinase and Neo-resistance gene was excised upon germline transmission. Southern blot confirmed recombination (J:91362)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pparg Mutation:  14 strains or lines available
Original:  J:91362 Tsai YS, et al., Hypertension and abnormal fat distribution but not insulin resistance in mice with P465L PPARgamma. J Clin Invest. 2004 Jul;114(2):240-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory