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Xisttm2.1Nbd
Targeted Allele Detail
Nomenclature
Symbol: Xisttm2.1Nbd
Name: inactive X specific transcripts; targeted mutation 2.1, Neil Brockdorff
MGI ID: MGI:3047785
Synonyms: Delta5'deltaneo
Gene: Xist  Location: ChrX:103460375-103483217 bp, - strand  Genetic Position: ChrX, 46.15 cM, cytoband D
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:85305
Parent Cell Line:  GK129 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsIn vitro cre expression excised the floxed PGK-neomycin resistance gene in Xisttm2Nbd. RT-PCR indicated ectopic sense transcription in mutants, putatively because of bidirectional activity of a Enox CpG island upstream of Xist. (J:85305)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xist Mutation:  6 strains or lines available
References
Original:  J:85305 Nesterova TB, et al., Skewing X chromosome choice by modulating sense transcription across the Xist locus. Genes Dev. 2003 Sep 1;17(17):2177-90
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory