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Pbx2tm1Mlc
Targeted Allele Detail
Nomenclature
Symbol: Pbx2tm1Mlc
Name: pre B cell leukemia homeobox 2; targeted mutation 1, Michael L Cleary
MGI ID: MGI:3047327
Synonyms: Pbx2-
Gene: Pbx2  Location: Chr17:34592471-34597341 bp, + strand  Genetic Position: Chr17, 18.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91079
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129S/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 248 bp portion of exon 3 and 68 bp of intron 3 were deleted and replaced with a PGK-neo cassette. Western blot of postnatal thymocytes and bone marrow cells indicated absence of protein. Western blot of fetal livers raised against a peptide mapping at the amino acid terminus detected neither full length nor truncated proteins. Northern blot also indicated no full length or truncated transcript. (J:91079)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pbx2 Mutation:  4 strains or lines available
Notes
ES cell line = W9.5 (129S1/Sv-p+ Tyr+ Kitl+) or GS (129S6/SvEvTac).
References
Original:  J:91079 Selleri L, et al., The TALE homeodomain protein Pbx2 is not essential for development and long-term survival. Mol Cell Biol. 2004 Jun;24(12):5324-31
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory