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Abcc4tm1Jsch
Targeted Allele Detail
Nomenclature
Symbol: Abcc4tm1Jsch
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 4; targeted mutation 1, John D Schuetz
MGI ID: MGI:3047326
Synonyms: Mrp4-
Gene: Abcc4  Location: Chr14:118482692-118706219 bp, - strand  Genetic Position: Chr14, 62.24 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:90692
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exon 27. Immunoblot analysis of membrane fractions showed complete loss of protein in mutants. (J:92788)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Abcc4 Mutation:  112 strains or lines available
References
Original:  J:90692 Assem M, et al., Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem. 2004 May 21;279(21):22250-7
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory