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Transgene Detail
Symbol: Tg(TTR-V30M)15Imeg
Name: transgene insertion 15, Institute of Molecular Embryology and Genetics
MGI ID: MGI:3047080
Synonyms: 6.0-hMet30, 6.0-Met30, Tg(6.0-hV30M)14Imeg, Tg(TTR)15Imeg, Tg(TTR-V30M)15Imeg, Tg(TTR-Val30Met)15Imeg
Transgene: Tg(TTR-V30M)15Imeg  Location: unknown  
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(TTR-V30M)15Imeg expresses 1 gene
Mutation detailsThe targeting construct contained 6.0 kb of the upstream region and the entire coding region of the human transthyretin gene. The coding sequence contained a methionine to valine substitution mutation at position 30. Transgenic transthyretin transcript was detected in liver, brain, kidney, and yolk sac. In some cases aberrant transcript that was larger than normal transcript was detected. (J:91391)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Of the eight transgenic lines produced in J:91391, 5 produced serum levels of transthyretin that were higher than those found in patients with familial amyloidotic polyneuropathy (FAP), these were lines: 15, 21, 24, 37 and 40.
Original:  J:91391 Nagata Y, et al., A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse. J Biochem. 1995 Jan;117(1):169-75
All:  15 reference(s)

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MGI 6.12
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