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Tg(TTR-V30M)15Imeg
Transgene Detail
Nomenclature
Symbol: Tg(TTR-V30M)15Imeg
Name: transgene insertion 15, Institute of Molecular Embryology and Genetics
MGI ID: MGI:3047080
Synonyms: 6.0-hMet30, 6.0-Met30, Tg(6.0-hV30M)14Imeg, Tg(TTR)15Imeg, Tg(TTR-V30M)15Imeg, Tg(TTR-Val30Met)15Imeg
Transgene: Tg(TTR-V30M)15Imeg  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Mutation details
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Of the eight transgenic lines produced in J:91391, 5 produced serum levels of transthyretin that were higher than those found in patients with familial amyloidotic polyneuropathy (FAP), these were lines: 15, 21, 24, 37 and 40.

References
Original:  J:91391 Nagata Y, et al., A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse. J Biochem. 1995 Jan;117(1):169-75
All:  10 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory