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Tg(TTR-V30M)15Imeg
Transgene Detail
Summary
Symbol: Tg(TTR-V30M)15Imeg
Name: transgene insertion 15, Institute of Molecular Embryology and Genetics
MGI ID: MGI:3047080
Synonyms: 6.0-hMet30, 6.0-Met30, Tg(6.0-hV30M)14Imeg, Tg(TTR)15Imeg, Tg(TTR-V30M)15Imeg, Tg(TTR-Val30Met)15Imeg
Transgene: Tg(TTR-V30M)15Imeg  Location: unknown  
Alliance: Tg(TTR-V30M)15Imeg page
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(TTR-V30M)15Imeg expresses 1 gene
 
Mutation detailsThe targeting construct contained 6.0 kb of the upstream region and the entire coding region of the human transthyretin gene. The coding sequence contained a methionine to valine substitution mutation at position 30. Transgenic transthyretin transcript was detected in liver, brain, kidney, and yolk sac. In some cases aberrant transcript that was larger than normal transcript was detected. (J:91391)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Notes
Of the eight transgenic lines produced in J:91391, 5 produced serum levels of transthyretin that were higher than those found in patients with familial amyloidotic polyneuropathy (FAP), these were lines: 15, 21, 24, 37 and 40.
References
Original:  J:91391 Nagata Y, et al., A 6-kb upstream region of the human transthyretin gene can direct developmental, tissue-specific, and quantitatively normal expression in transgenic mouse. J Biochem. 1995 Jan;117(1):169-75
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory