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Mybtm1.1Cgn
Targeted Allele Detail
Nomenclature
Symbol: Mybtm1.1Cgn
Name: myeloblastosis oncogene; targeted mutation 1.1, University of Cologne
MGI ID: MGI:3047076
Synonyms: Myb-, Mybd
Gene: Myb  Location: Chr10:21124936-21160905 bp, - strand  Genetic Position: Chr10, 9.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91122
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsCrossing of Mybtm1Cgn with mice expressing Cre under the control of an hCMV promoter excised floxed exon 2, leaving a single loxP site. Southern blot confirmed recombination and Western blot of fetal livers showed lack of protein in mutants. (J:91122)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myb Mutation:  22 strains or lines available
References
Original:  J:91122 Bender TP, et al., Critical functions for c-Myb at three checkpoints during thymocyte development. Nat Immunol. 2004 Jul;5(7):721-9
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory