Prnd^tm1Dwm
Targeted Allele Detail

Summary

• Symbol: Prnd^tm1Dwm
• Name: prion like protein doppel; targeted mutation 1, David W Melton
• MGI ID: MGI:3047060
• Synonyms: Prnd^-
• Gene: Prnd Location: Chr2:131792781-131798050 bp, + strand Genetic Position: Chr2, 64.07 cM
• Alliance: Prnd^tm1Dwm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91094
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The ORF (except for the last 31 bases) and 713 bases upstream were replaced by an Hprt minigene. Western blotting of mutant testis lysates indicated absence of protein. (J:91094)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prnd Mutation: 6 strains or lines available

References

• Original: J:91094 Paisley D, et al., Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am J Pathol. 2004 Jun;164(6):2279-88
• All: 1 reference(s)