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Hyou1tm1Oga
Targeted Allele Detail
Nomenclature
Symbol: Hyou1tm1Oga
Name: hypoxia up-regulated 1; targeted mutation 1, Satoshi Ogawa
MGI ID: MGI:3046998
Gene: Hyou1  Location: Chr9:44379490-44392369 bp, + strand  Genetic Position: Chr9, 24.84 cM, cytoband B
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:91396
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neo cassette replaced exons 8-10 via homologous recombination. Southern blot confirmed successful recombination. Immunoblotting of heterozygous mice indicated presence of the full-length protein only and not the predicted 226 amino acid long truncated protein, indicating that the mutation results in a null allele. (J:91396)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hyou1 Mutation:  22 strains or lines available
References
Original:  J:91396 Kitao Y, et al., Expression of the endoplasmic reticulum molecular chaperone (ORP150) rescues hippocampal neurons from glutamate toxicity. J Clin Invest. 2001 Nov;108(10):1439-50
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/12/2017
MGI 6.10
The Jackson Laboratory