En1^{tm1(Wnt1)Wrst}
Targeted Allele Detail

Summary

• Symbol: En1^{tm1(Wnt1)Wrst}
• Name: engrailed 1; targeted mutation 1, Wolfgang Wurst
• MGI ID: MGI:3046939
• Synonyms: En1^Wnt1
• Gene: En1 Location: Chr1:120530246-120535719 bp, + strand Genetic Position: Chr1, 52.74 cM, cytoband C2-qter
• Alliance: En1^{tm1(Wnt1)Wrst} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91004
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: Wnt1 was knocked-in to the endogenous En1 locus. Exon 1 was replaced with Wnt1 and an IRES-lacZ and floxed neo. In situ hybridization indicates Wnt1 expression was expanded according to the En1 expression pattern. (J:91004)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any En1 Mutation: 32 strains or lines available

References

• Original: J:91004 Panhuysen M, et al., Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region. Mol Cell Neurosci. 2004 May;26(1):101-11
• All: 4 reference(s)